Paget disease of the bone
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Paget disease of the bone

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Published: July 22, 2026 | Last Reviewed: July 22, 2026 | Medically Reviewed by: Dr. Sarah Mitchell, MD, Geriatrics | Reading Time: 5 min




Key Takeaways

  • Understanding paget disease bone senior fall prevention is important for seniors and their caregivers.
  • Most people with the condition have no symptoms.
  • Tests that may indicate Paget disease include:
  • Not all people with Paget disease need to be treated.
  • People with this condition may benefit from taking part in support groups for people with similar experiences.

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What Are the Common Causes and Risk Factors?

Understanding paget disease bone senior fall prevention is important for seniors and their caregivers. the cause of Paget disease is unknown. It may be due to genetic factors, but also could be due to a viral infection early in life or hypersensitivity to vitamin D.

The disease occurs worldwide, but is more common in Europe, Australia, and New Zealand. The disease has become much less common over the last 50 years.

In people with Paget disease, there is an abnormal breakdown of bone tissue in specific areas. This is followed by abnormal bone formation. The new area of bone is larger, but weaker. The new bone is also filled with new blood vessels.

The affected bone may only be in one or two areas of the skeleton, or in many different bones in the body. It more often involves bones of the arms, collarbones, legs, pelvis, spine, and skull.

What Are the Symptoms and Warning Signs?

Most people with the condition have no symptoms. Paget disease is often diagnosed when an

x-ray

is done for another reason. It may also be discovered when trying to find the cause of high blood calcium levels.

If they do occur, symptoms may include:

  • Bone pain

    , joint pain or stiffness, and neck pain (the pain may be severe and be present most of the time)

  • Bowing of the legs and other visible deformities
  • Enlarged head and skull deformities

  • Fracture

  • Headache

  • Hearing loss

  • Reduced height
  • Warm skin over the affected bone
📖 What Are Exams and Tests?

What Are Exams and Tests?

Tests that may indicate Paget disease include:

  • Bone scan

  • Bone x-ray

  • Elevated markers of bone breakdown (for example, N-telopeptide or procollagen type I N-terminal propeptide (PINP))

This disease may also affect the results of the following tests:

  • Alkaline phosphatase (ALP)

    , bone specific isoenzyme

  • Serum calcium

📖 How Is It Treated?

How Is It Treated?

Not all people with Paget disease need to be treated. People who may not need treatment include those who:

  • Only have mildly abnormal blood tests or x-ray or bone scan findings
  • Have no symptoms and no evidence of active disease

Paget disease is commonly treated when:

  • Certain bones, such as weight-bearing bones, are involved and the risk of fracture is higher.
  • Bony changes are getting worse quickly (treatment can reduce the risk of fractures).
  • Bony deformities are present.
  • A person has pain or other symptoms.
  • The skull is affected. (This is to prevent hearing loss.)
  • The serum calcium levels are elevated and causing symptoms.

Certain medicines may prevent further bone breakdown and formation. Currently, there are several classes of medicines used to treat Paget disease. These include:

  • Bisphosphonates: These medicines are the first treatment, and they help decrease bone remodeling. Medicines are commonly taken by mouth, or given through a vein (intravenously).
  • Calcitonin: This hormone is involved in bone metabolism. It may be given as a nasal spray (Miacalcin), or as an injection under the skin (Calcimar or Mithracin).
  • Denosumab: This monoclonal antibody (commonly used for treatment of osteoporosis) may be used.

Acetaminophen (Tylenol) or nonsteroidal anti-inflammatory drugs (NSAIDs) may also be given for pain. In severe cases, orthopedic surgery may be needed to correct a deformity or fracture.

📖 What Are Support Groups?

What Are Support Groups?

People with this condition may benefit from taking part in support groups for people with similar experiences.

📖 What Is Outlook (Prognosis)?

What Is Outlook (Prognosis)?

Most of the time, the condition can be managed with medicines. A small number of people may develop a cancer of the bone called

osteosarcoma

. Some people will need joint replacement surgery.

📖 What Are Possible Complications?

What Are Possible Complications?

Complications may include:

  • Bone fractures
  • Deafness
  • Deformities
  • Heart failure

  • Hypercalcemia

  • Paraplegia

  • Spinal stenosis

📖 When to Contact a Medical Professional?

When to Contact a Medical Professional?

Contact your health care provider if you develop symptoms of Paget disease.

Osteitis deformans; Paget’s disease of the bone

  • X-ray

    X-ray

Geiger CD, Devereaux MW, Hart D. Disorders of bones, joints, ligaments, and meninges. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds.

Bradley and Daroff’s Neurology in Clinical Practice

. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 104.

Ralston SH. Paget disease of bone. In: Goldman L, Cooney KA, eds.

Goldman-Cecil Medicine

. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 228.

Singer FR. Paget disease of bone. In: Robertson RP, ed.

DeGroot’s Endocrinology

. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 63.

Updated by: Sandeep K. Dhaliwal, MD, board-certified in Diabetes, Endocrinology, and Metabolism, Springfield, VA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.


  • Paget’s Disease of Bone

Frequently Asked Questions

Key Takeaways

Understanding paget disease bone senior fall prevention is important for seniors and their caregivers. Most people with the condition have no symptoms. Tests that may indicate Paget disease include:
Not all people with Paget disease need to be treated.

What Are the Common Causes and Risk Factors?

Understanding paget disease bone senior fall prevention is important for seniors and their caregivers. the cause of Paget disease is unknown. It may be due to genetic factors, but also could be due to a viral infection early in life or hypersensitivity to vitamin D.

What Are the Symptoms and Warning Signs?

Most people with the condition have no symptoms. Paget disease is often diagnosed when an

x-ray

is done for another reason. It may also be discovered when trying to find the cause of high blood calcium levels.

What Are Exams and Tests?

Tests that may indicate Paget disease include:

Bone scan

Bone x-ray

Elevated markers of bone breakdown (for example, N-telopeptide or procollagen type I N-terminal propeptide (PINP))

This disease may also affect the results of the following tests:

Alkaline phosphatase (ALP)

, bone specific isoenzyme

Serum calcium

📖 How Is It Treated?

How Is It Treated?

Not all people with Paget disease need to be treated. People who may not need treatment include those who:

Only have mildly abnormal blood tests or x-ray or bone scan findings

Have no symptoms and no evidence of active disease

Paget disease is commonly treated when:

Certain bones, such as weight-bearing bones, are involved and the risk of fracture is higher. Bony changes are getting worse quickly (treatment can reduce the risk of fractures).

About the Author: This article was researched and written by the SilverWell Hub editorial team. It was medically reviewed by Dr. Sarah Mitchell, MD, Geriatrics.

Sources: This article is adapted from MedlinePlus, a service of the National Library of Medicine.

Disclaimer: This information is for educational purposes only. See our full Medical Disclaimer.

Published: July 22, 2026 | Next review: January 2027